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In order to find out the relationship between contained water and coloring rate of thiamine monosalts in preparations, three kinds of thiamine monorhodanate, -monoiodide, -monobromide were manufactured and investigated as powders, granules and compressed tablets, respectively. Apparent coloring rate constants and solubility in accordance with temperature changes were measured. Nature of contained water and coloration of thiamine monosalts in preparations was examined in detail. It was thereby found that if water attached in a free state, coloration occurred whose degree was approximately proportional to the quantity of such water, and a linear relation was found to hold between the logarithm of the apparent coloring rate constants and the reciprocal of the absolute temperature in granules and compressed tablets.
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